175161

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2336035..2336552 Replicon chromosome
Accession NZ_CP062416
Organism Staphylococcus aureus strain NAS_AN_149

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF719_RS11370 Protein ID WP_000113262.1
Coordinates 2336286..2336552 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF719_RS11365 Protein ID WP_000584499.1
Coordinates 2336035..2336286 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF719_RS11335 (2331733) 2331733..2332452 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF719_RS11340 (2332449) 2332449..2333180 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF719_RS11345 (2333277) 2333277..2334527 - 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
IF719_RS11350 (2334782) 2334782..2335144 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF719_RS11355 (2335163) 2335163..2335762 + 600 WP_000162803.1 DsbA family protein -
IF719_RS11360 (2335790) 2335790..2335870 + 81 WP_223197974.1 hypothetical protein -
IF719_RS11365 (2336035) 2336035..2336286 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF719_RS11370 (2336286) 2336286..2336552 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF719_RS11375 (2336587) 2336587..2336658 + 72 WP_223200558.1 hypothetical protein -
IF719_RS11380 (2336846) 2336846..2338396 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF719_RS11385 (2338582) 2338582..2339049 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF719_RS11390 (2339136) 2339136..2339318 + 183 WP_000079142.1 hypothetical protein -
IF719_RS11395 (2339535) 2339535..2340359 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF719_RS11400 (2340593) 2340593..2341129 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T175161 WP_000113262.1 NZ_CP062416:2336286-2336552 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T175161 NZ_CP081791:186544-186651 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT175161 WP_000584499.1 NZ_CP062416:2336035-2336286 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT175161 NZ_CP081791:c186486-186429 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References