Detailed information of TA system TA175159

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2310996..2311180
• Replicon: chromosome
• Accession: NZ_CP062416
• Organism: Staphylococcus aureus strain NAS_AN_149

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF719_RS11235
• Protein ID: WP_000482650.1
• Coordinates: 2310996..2311103 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2311120..2311180 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF719_RS11210	2306368..2306841	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF719_RS11215	2306964..2308175	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF719_RS11220	2308357..2309016	-	660	WP_000831298.1	membrane protein	-
IF719_RS11225	2309076..2310218	-	1143	WP_001176863.1	glycerate kinase	-
IF719_RS11230	2310476..2310862	+	387	WP_000779358.1	flippase GtxA	-
IF719_RS11235	2310996..2311103	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2311120..2311180	-	61	-	-	Antitoxin
IF719_RS11240	2311751..2313514	+	1764	WP_001064820.1	ABC transporter ATP-binding protein	-
IF719_RS11245	2313539..2315272	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF719_RS11250	2315503..2315670	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T175159 WP_000482650.1 NZ_CP062416:2310996-2311103 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175159 NZ_CP081789:1929-2966 [Escherichia coli]
ATGGCACAGAACCCATTTAAAGCACTAAATATTAATACAGACAAGATTGAAGCTGCCTTGACGCAGAATGGCGTCACAAA
CTTTTCTTCTATCGTGAGAAACGAAAGAGAAACACATTTATCAGGGACATATAAAGAAATAGATTTTTTAATAAAGCTAA
TGCCATCAGGTGGAAACACCACTATAGGAAGGGCATCAGGACAAAACAACACTTACTTTGATGAGATCGCTGGCATTATA
AAAGAAAACTGTTTGTATTCAGATAAAAAAACGTTTGAATACACAATCCCAAGATTCAGCGATGAAAATAAGGAAATGTT
GTTTGCATTTCTTACTGAAGAAAACGTAAAAATAGAAGAAGATAAAAACAACGACCCCAACTGTAAACATCAATACATCA
TGACCACTGGCAATGGTGACAGAGTCAGAGCAAAAATTTACAACCGTGGCTCAATTCAATTCCAAGGTAAATATCTTCAA
ATCGCAAGTTTGATTAATGATTTCATGTGCACCATACTGGACATGAAAGAGATTATAGAACAGAAGAATCAAGAATTTAA
TGTTGACATAAAAAAAGAAACAATTGAGTCAGAATTACATAGTAAACTACCAAAAAGCATCGACCTAATCCATGACGACA
TCAAAAAACAGCTATCCTGCTCGCTCATAATGAAACAAATAGATGTCGAAATGGAAGATTACTCAACATATTGTTTCTCA
GCCTTAAGATCCATAGAAGGCTTTATATATCAACTACTTGGAAGCGTATGCAACCCATCATCATCAAGGAATCTTGGCGA
GTACTTCACTGAGAATAACCCGAAATACATAATAAGAGATATACACCAAGAAACTATTAATGGTGAAATAGCAGAAGTTT
TGTGTGAGTGCTACACTTACTGGCATGAAAACAGACATGGCTTGTTCCATATGAAACCAGGTGTGGCTGACACTAAGACA
ATTGACAAAGCAGAATCTATTGAAATTATCGATACTGTATGTCAGTTGATAGATAAAGGCATGGCTAGGTTGAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175159 NZ_CP062416:c2311180-2311120 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin