Detailed information of TA system TA175151

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18899..19237
• Replicon: chromosome
• Accession: NZ_CP062416
• Organism: Staphylococcus aureus strain NAS_AN_149

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: IF719_RS00100
• Protein ID: WP_072353918.1
• Coordinates: 18899..19075 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19063..19237 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF719_RS00080	14066..17848	+	3783	WP_031806961.1	phage tail spike protein	-
IF719_RS00085	17841..17993	+	153	WP_001000058.1	hypothetical protein	-
IF719_RS00090	18039..18326	+	288	WP_001262620.1	hypothetical protein	-
IF719_RS00095	18382..18756	+	375	WP_000340977.1	hypothetical protein	-
IF719_RS00100	18899..19075	+	177	WP_072353918.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19063..19237	-	175	-	-	Antitoxin
IF719_RS00110	19287..19541	+	255	WP_000611512.1	phage holin	-
IF719_RS00115	19553..20308	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF719_RS00120	20499..20990	+	492	WP_000919350.1	staphylokinase	-
IF719_RS00125	21640..21975	+	336	Protein_25	SH3 domain-containing protein	-
IF719_RS00130	22070..22519	-	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
IF719_RS00135	23201..23551	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
IF719_RS00140	23604..23864	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1..23551	23550

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T175151 WP_072353918.1 NZ_CP062416:18899-19075 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T175151 NZ_CP081782:c4339027-4338677 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT175151 NZ_CP062416:c19237-19063 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin