Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2901192..2901615 Replicon chromosome
Accession NZ_CP062415
Organism Staphylococcus aureus strain NAS_AN_150

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag IF720_RS14515 Protein ID WP_001065091.1
Coordinates 2901192..2901443 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag IF720_RS14520 Protein ID WP_000028422.1
Coordinates 2901433..2901615 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF720_RS14470 (2896847) 2896847..2897767 + 921 WP_000138472.1 recombinase RecT -
IF720_RS14475 (2897848) 2897848..2898465 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
IF720_RS14480 (2898466) 2898466..2898936 + 471 WP_000934764.1 single-stranded DNA-binding protein -
IF720_RS14485 (2898966) 2898966..2899850 + 885 WP_000148316.1 DnaD domain protein -
IF720_RS14490 (2899857) 2899857..2900075 + 219 WP_000338531.1 hypothetical protein -
IF720_RS14495 (2900084) 2900084..2900393 + 310 Protein_2822 RusA family crossover junction endodeoxyribonuclease -
IF720_RS14500 (2900406) 2900406..2900774 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
IF720_RS14505 (2900778) 2900778..2901020 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
IF720_RS14510 (2901035) 2901035..2901199 + 165 WP_000990744.1 hypothetical protein -
IF720_RS14515 (2901192) 2901192..2901443 + 252 WP_001065091.1 DUF1024 family protein Toxin
IF720_RS14520 (2901433) 2901433..2901615 + 183 WP_000028422.1 hypothetical protein Antitoxin
IF720_RS14525 (2901608) 2901608..2902150 + 543 WP_000185659.1 dUTP pyrophosphatase -
IF720_RS14530 (2902187) 2902187..2902393 + 207 WP_000195803.1 DUF1381 domain-containing protein -
IF720_RS14535 (2902390) 2902390..2902776 + 387 WP_000592207.1 hypothetical protein -
IF720_RS14540 (2902773) 2902773..2902922 + 150 WP_000595265.1 transcriptional activator RinB -
IF720_RS14545 (2902922) 2902922..2903122 + 201 WP_000265043.1 DUF1514 family protein -
IF720_RS14550 (2903150) 2903150..2903566 + 417 WP_000590122.1 hypothetical protein -
IF720_RS14555 (2903798) 2903798..2904097 + 300 WP_000988336.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / tsst-1 / hlb 2861321..2904097 42776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T175150 WP_001065091.1 NZ_CP062415:2901192-2901443 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T175150 NZ_CP081782:c4257518-4257231 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT175150 WP_000028422.1 NZ_CP062415:2901433-2901615 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT175150 NZ_CP081782:c4257244-4256942 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References