Detailed information of TA system TA175141

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2445796..2445980
• Replicon: chromosome
• Accession: NZ_CP062415
• Organism: Staphylococcus aureus strain NAS_AN_150

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF720_RS12060
• Protein ID: WP_000482647.1
• Coordinates: 2445796..2445903 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2445920..2445980 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF720_RS12035	2441158..2441631	+	474	WP_000456496.1	GyrI-like domain-containing protein	-
IF720_RS12040	2441754..2442965	-	1212	WP_001191919.1	multidrug effflux MFS transporter	-
IF720_RS12045	2443147..2443806	-	660	WP_000831298.1	membrane protein	-
IF720_RS12050	2443866..2445008	-	1143	WP_240111970.1	glycerate kinase	-
IF720_RS12055	2445276..2445662	+	387	WP_000779351.1	flippase GtxA	-
IF720_RS12060	2445796..2445903	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2445920..2445980	-	61	-	-	Antitoxin
IF720_RS12065	2446551..2448314	+	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
IF720_RS12070	2448339..2450072	+	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
IF720_RS12075	2450303..2450470	+	168	Protein_2352	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T175141 WP_000482647.1 NZ_CP062415:2445796-2445903 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175141 NZ_CP081782:1970097-1970351 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175141 NZ_CP062415:c2445980-2445920 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin