Detailed information of TA system TA175137

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 556590..557169
• Replicon: chromosome
• Accession: NZ_CP062415
• Organism: Staphylococcus aureus strain NAS_AN_150

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: IF720_RS03085
• Protein ID: WP_001025401.1
• Coordinates: 556590..556835 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	556804..557169 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF720_RS03035 (552841)	552841..553455	+	615	WP_000191466.1	hypothetical protein	-
IF720_RS03040 (553452)	553452..553598	-	147	WP_240112013.1	hypothetical protein	-
IF720_RS03045 (553635)	553635..553817	-	183	WP_000705240.1	hypothetical protein	-
IF720_RS03050 (553887)	553887..554573	-	687	WP_000177667.1	XRE family transcriptional regulator	-
IF720_RS03055 (554770)	554770..554988	+	219	WP_031783263.1	helix-turn-helix transcriptional regulator	-
IF720_RS03060 (555029)	555029..555472	+	444	WP_000435357.1	hypothetical protein	-
IF720_RS03065 (555487)	555487..555636	+	150	WP_000771849.1	hypothetical protein	-
IF720_RS03070 (555677)	555677..555889	-	213	WP_000362644.1	hypothetical protein	-
IF720_RS03075 (555959)	555959..556156	+	198	WP_001148860.1	hypothetical protein	-
IF720_RS03080 (556143)	556143..556523	-	381	WP_240112014.1	DUF2513 domain-containing protein	-
IF720_RS03085 (556590)	556590..556835	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
IF720_RS03090 (556804)	556804..557169	-	366	WP_001128433.1	hypothetical protein	Antitoxin
IF720_RS03095 (557224)	557224..557439	+	216	WP_001097553.1	hypothetical protein	-
IF720_RS03100 (557464)	557464..557727	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
IF720_RS03105 (557739)	557739..557900	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
IF720_RS03110 (557979)	557979..558302	+	324	WP_000174998.1	hypothetical protein	-
IF720_RS03115 (558317)	558317..558679	+	363	WP_000279448.1	hypothetical protein	-
IF720_RS03120 (558676)	558676..559842	+	1167	WP_000762531.1	DUF2800 domain-containing protein	-
IF720_RS03125 (559868)	559868..560425	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T175137 WP_001025401.1 NZ_CP062415:556590-556835 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T175137 NZ_CP081782:1046792-1047127 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAAGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT175137 NZ_CP062415:c557169-556804 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin