Detailed information of TA system TA175135

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 222875..223055
• Replicon: chromosome
• Accession: NZ_CP062415
• Organism: Staphylococcus aureus strain NAS_AN_150

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF720_RS01420
• Protein ID: WP_001801861.1
• Coordinates: 222960..223055 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	222875..222932 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF720_RS01395	218289..220708	-	2420	Protein_241	polysaccharide lyase 8 family protein	-
IF720_RS01400	221233..221675	+	443	Protein_242	DUF1433 domain-containing protein	-
IF720_RS01405	221675..222118	+	444	WP_000731421.1	DUF1433 domain-containing protein	-
IF720_RS01410	222118..222561	+	444	WP_240111998.1	DUF1433 domain-containing protein	-
IF720_RS01415	222736..222837	-	102	WP_001791232.1	hypothetical protein	-
-	222875..222932	+	58	-	-	Antitoxin
IF720_RS01420	222960..223055	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF720_RS01425	223506..223952	+	447	WP_000747804.1	DUF1433 domain-containing protein	-
IF720_RS01430	224145..224714	+	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
IF720_RS01435	224714..226081	+	1368	WP_001093574.1	FRG domain-containing protein	-
IF720_RS01440	226230..226802	-	573	WP_000414222.1	hypothetical protein	-
IF720_RS01445	226900..227244	-	345	WP_000627550.1	DUF3969 family protein	-
IF720_RS01450	227285..227911	-	627	WP_000669038.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hysA / hysA	193124..229677	36553

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T175135 WP_001801861.1 NZ_CP062415:c223055-222960 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T175135 NZ_CP081782:775346-775642 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT175135 NZ_CP062415:222875-222932 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin