Detailed information of TA system TA175131

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 22041..22379
• Replicon: chromosome
• Accession: NZ_CP062415
• Organism: Staphylococcus aureus strain NAS_AN_150

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF720_RS00110
• Protein ID: WP_011447039.1
• Coordinates: 22041..22217 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	22205..22379 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF720_RS00090	19822..19974	+	153	WP_001153681.1	hypothetical protein	-
IF720_RS00095	20021..20308	+	288	WP_001040259.1	hypothetical protein	-
IF720_RS00100	20364..20738	+	375	WP_000340977.1	hypothetical protein	-
IF720_RS00105	21159..21932	+	774	WP_000750406.1	staphylococcal enterotoxin type A	-
IF720_RS00110	22041..22217	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	22205..22379	-	175	-	-	Antitoxin
IF720_RS00120	22429..22683	+	255	WP_000611512.1	phage holin	-
IF720_RS00125	22695..23450	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF720_RS00130	23642..24133	+	492	WP_000919350.1	staphylokinase	-
IF720_RS00135	24783..25118	+	336	Protein_27	SH3 domain-containing protein	-
IF720_RS00140	25213..25662	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
IF720_RS00145	26348..26698	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF720_RS00150	26751..27011	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / chp / scn / hlb / map	1..32472	32471

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T175131 WP_011447039.1 NZ_CP062415:22041-22217 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T175131 NZ_CP081775:c264555-264271 [Escherichia coli]
GTGTATAAACTCACTGAACGGGCAGCAGACGACTTCGCCGGGATTTATGACTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAGACACTGGCCGGAATGCCAGATATGGGACGTGACTACCATA
CCGTTCCTGGTGTGATGCGCATTGAATTTCAGCGACATGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCG
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT175131 NZ_CP062415:c22379-22205 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin