Detailed information of TA system TA175126

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2592789..2593067
• Replicon: chromosome
• Accession: NZ_CP062414
• Organism: Staphylococcus aureus strain NAS_AN_175

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF723_RS12715
• Protein ID: WP_001802298.1
• Coordinates: 2592789..2592893 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2592889..2593067 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF723_RS12695	2589586..2590368	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF723_RS12700	2590436..2591293	+	858	WP_000370928.1	HAD family hydrolase	-
IF723_RS12705	2591951..2592109	-	159	WP_001792784.1	hypothetical protein	-
IF723_RS12710	2592102..2592272	-	171	WP_001792292.1	transposase	-
IF723_RS12715	2592789..2592893	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2592889..2593067	-	179	-	-	Antitoxin
IF723_RS12725	2593392..2594483	-	1092	WP_000495681.1	hypothetical protein	-
IF723_RS12730	2594749..2595729	-	981	WP_240113281.1	CDF family zinc efflux transporter CzrB	-
IF723_RS12735	2595731..2596051	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF723_RS12740	2596203..2596868	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175126 WP_001802298.1 NZ_CP062414:2592789-2592893 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175126 NZ_CP081774:c4337692-4337342 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT175126 NZ_CP062414:c2593067-2592889 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin