Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2311662..2311846 Replicon chromosome
Accession NZ_CP062414
Organism Staphylococcus aureus strain NAS_AN_175

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag IF723_RS11250 Protein ID WP_000482650.1
Coordinates 2311662..2311769 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2311786..2311846 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF723_RS11225 2307034..2307507 + 474 WP_000456489.1 GyrI-like domain-containing protein -
IF723_RS11230 2307630..2308841 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
IF723_RS11235 2309023..2309682 - 660 WP_000831298.1 membrane protein -
IF723_RS11240 2309742..2310884 - 1143 WP_001176863.1 glycerate kinase -
IF723_RS11245 2311142..2311528 + 387 WP_000779358.1 flippase GtxA -
IF723_RS11250 2311662..2311769 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2311786..2311846 - 61 - - Antitoxin
IF723_RS11255 2312417..2314180 + 1764 WP_001064820.1 ABC transporter ATP-binding protein -
IF723_RS11260 2314205..2315938 + 1734 WP_000486494.1 ABC transporter ATP-binding protein -
IF723_RS11265 2316169..2316336 + 168 WP_001792506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T175122 WP_000482650.1 NZ_CP062414:2311662-2311769 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T175122 NZ_CP081774:3701371-3701589 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT175122 NZ_CP062414:c2311846-2311786 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References