Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2773644..2774058 Replicon chromosome
Accession NZ_CP062413
Organism Staphylococcus aureus strain NAS_AN_176

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF724_RS13790 Protein ID WP_001065046.1
Coordinates 2773644..2773895 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF724_RS13795 Protein ID WP_000028424.1
Coordinates 2773885..2774058 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF724_RS13750 (2769301) 2769301..2770221 + 921 WP_000138475.1 recombinase RecT -
IF724_RS13755 (2770302) 2770302..2770919 + 618 WP_072353921.1 MBL fold metallo-hydrolase -
IF724_RS13760 (2770920) 2770920..2771390 + 471 WP_000934762.1 single-stranded DNA-binding protein -
IF724_RS13765 (2771420) 2771420..2772313 + 894 WP_000148327.1 DnaD domain-containing protein -
IF724_RS13770 (2772320) 2772320..2772538 + 219 WP_000338527.1 hypothetical protein -
IF724_RS13775 (2772547) 2772547..2773002 + 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
IF724_RS13780 (2773015) 2773015..2773383 + 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
IF724_RS13785 (2773387) 2773387..2773629 + 243 WP_000131381.1 phi PVL orf 51-like protein -
IF724_RS13790 (2773644) 2773644..2773895 + 252 WP_001065046.1 DUF1024 family protein Toxin
IF724_RS13795 (2773885) 2773885..2774058 + 174 WP_000028424.1 hypothetical protein Antitoxin
IF724_RS13800 (2774084) 2774084..2774341 + 258 WP_031866878.1 hypothetical protein -
IF724_RS13805 (2774342) 2774342..2774503 + 162 WP_000889682.1 hypothetical protein -
IF724_RS13810 (2774518) 2774518..2775051 + 534 WP_001061838.1 dUTPase -
IF724_RS13815 (2775088) 2775088..2775333 + 246 WP_001282074.1 hypothetical protein -
IF724_RS13820 (2775330) 2775330..2775536 + 207 WP_000195803.1 DUF1381 domain-containing protein -
IF724_RS13825 (2775533) 2775533..2775919 + 387 WP_000592201.1 hypothetical protein -
IF724_RS13830 (2775916) 2775916..2776065 + 150 WP_000595305.1 transcriptional activator RinB -
IF724_RS13835 (2776224) 2776224..2776874 + 651 WP_001005262.1 hypothetical protein -
IF724_RS13840 (2776874) 2776874..2777074 + 201 WP_000265041.1 DUF1514 family protein -
IF724_RS13845 (2777097) 2777097..2777567 + 471 WP_000282758.1 hypothetical protein -
IF724_RS13850 (2777682) 2777682..2778134 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
IF724_RS13855 (2778150) 2778150..2778494 + 345 WP_000817289.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlb 2757311..2779089 21778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T175113 WP_001065046.1 NZ_CP062413:2773644-2773895 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T175113 NZ_CP081774:1117928-1118239 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT175113 WP_000028424.1 NZ_CP062413:2773885-2774058 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT175113 NZ_CP081774:1118236-1118655 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References