Detailed information of TA system TA175107

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2626190..2626452
• Replicon: chromosome
• Accession: NZ_CP062413
• Organism: Staphylococcus aureus strain NAS_AN_176

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF724_RS12985
• Protein ID: WP_001802298.1
• Coordinates: 2626190..2626294 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2626289..2626452 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF724_RS12970	2622987..2623769	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IF724_RS12975	2623837..2624694	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
IF724_RS12980	2625352..2625510	-	159	WP_001792784.1	hypothetical protein	-
IF724_RS12985	2626190..2626294	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2626289..2626452	-	164	-	-	Antitoxin
IF724_RS12995	2626727..2627818	-	1092	WP_000495669.1	hypothetical protein	-
IF724_RS13000	2628084..2629061	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IF724_RS13005	2629063..2629383	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF724_RS13010	2629535..2630200	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175107 WP_001802298.1 NZ_CP062413:2626190-2626294 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175107 NZ_CP081772:3265-4302 [Escherichia coli]
ATGGCACAGAACCCATTTAAAGCACTAAATATTAATACAGACAAGATTGAAGCTGCCTTGACGCAGAATGGCGTCACAAA
CTTTTCTTCTATCGTGAGAAACGAAAGAGAAACACATTTATCAGGGACATATAAAGAAATAGATTTTTTAATAAAGCTAA
TGCCATCAGGTGGAAACACCACTATAGGAAGGGCATCAGGACAAAACAACACTTACTTTGATGAGATCGCTGGCATTATA
AAAGAAAACTGTTTGTATTCAGATAAAAAAACGTTTGAATACACAATCCCAAGATTCAGCGATGAAAATAAGGAAATGTT
GTTTGCATTTCTTACTGAAGAAAACGTAAAAATAGAAGAAGATAAAAACAACGACCCCAACTGTAAACATCAATACATCA
TGACCACTGGCAATGGTGACAGAGTCAGAGCAAAAATTTACAACCGTGGCTCAATTCAATTCCAAGGTAAATATCTTCAA
ATCGCAAGTTTGATTAATGATTTCATGTGCACCATACTGGACATGAAAGAGATTATAGAACAGAAGAATCAAGAATTTAA
TGTTGACATAAAAAAAGAAACAATTGAGTCAGAATTACATAGTAAACTACCAAAAAGCATCGACCTAATCCATGACGACA
TCAAAAAACAGCTATCCTGCTCGCTCATAATGAAACAAATAGATGTCGAAATGGAAGATTACTCAACATATTGTTTCTCA
GCCTTAAGATCCATAGAAGGCTTTATATATCAACTACTTGGAAGCGTATGCAACCCATCATCATCAAGGAATCTTGGCGA
GTACTTCACTGAGAATAACCCGAAATACATAATAAGAGATATACACCAAGAAACTATTAATGGTGAAATAGCAGAAGTTT
TGTGTGAGTGCTACACTTACTGGCATGAAAACAGACATGGCTTGTTCCATATGAAACCAGGTGTGGCTGACACTAAGACA
ATTGACAAAGCAGAATCTATTGAAATTATCGATACTGTATGTCAGTTGATAGATAAAGGCATGGCTAGGTTGAAATAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT175107 NZ_CP062413:c2626452-2626289 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin