Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2364797..2365314 Replicon chromosome
Accession NZ_CP062413
Organism Staphylococcus aureus strain NAS_AN_176

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag IF724_RS11630 Protein ID WP_000113265.1
Coordinates 2365048..2365314 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF724_RS11625 Protein ID WP_000584499.1
Coordinates 2364797..2365048 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF724_RS11595 (2360494) 2360494..2361213 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF724_RS11600 (2361210) 2361210..2361941 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF724_RS11605 (2362038) 2362038..2363288 - 1251 WP_240104165.1 FemA/FemB family glycyltransferase FmhA -
IF724_RS11610 (2363544) 2363544..2363906 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF724_RS11615 (2363925) 2363925..2364524 + 600 WP_000162810.1 DsbA family protein -
IF724_RS11620 (2364552) 2364552..2364632 + 81 WP_223197974.1 hypothetical protein -
IF724_RS11625 (2364797) 2364797..2365048 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF724_RS11630 (2365048) 2365048..2365314 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
IF724_RS11635 (2365349) 2365349..2365420 + 72 Protein_2259 hypothetical protein -
IF724_RS11640 (2365609) 2365609..2367156 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF724_RS11645 (2367342) 2367342..2367809 + 468 WP_000153347.1 SRPBCC domain-containing protein -
IF724_RS11650 (2367893) 2367893..2368075 + 183 WP_000230292.1 hypothetical protein -
IF724_RS11655 (2368292) 2368292..2369116 + 825 WP_000572038.1 formate/nitrite transporter family protein -
IF724_RS11660 (2369350) 2369350..2369886 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T175106 WP_000113265.1 NZ_CP062413:2365048-2365314 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T175106 NZ_CP081770:c59535-59224 [Escherichia coli]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT175106 WP_000584499.1 NZ_CP062413:2364797-2365048 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT175106 NZ_CP081770:c59227-58808 [Escherichia coli]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTTCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References