Detailed information of TA system TA175104

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2338114..2338298
• Replicon: chromosome
• Accession: NZ_CP062413
• Organism: Staphylococcus aureus strain NAS_AN_176

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF724_RS11485
• Protein ID: WP_000482652.1
• Coordinates: 2338114..2338221 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2338238..2338298 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF724_RS11460	2333476..2333949	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
IF724_RS11465	2334072..2335283	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF724_RS11470	2335465..2336124	-	660	WP_000831298.1	membrane protein	-
IF724_RS11475	2336184..2337326	-	1143	WP_001176863.1	glycerate kinase	-
IF724_RS11480	2337594..2337980	+	387	WP_000779360.1	flippase GtxA	-
IF724_RS11485	2338114..2338221	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2338238..2338298	-	61	-	-	Antitoxin
IF724_RS11490	2338924..2340687	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
IF724_RS11495	2340712..2342445	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
IF724_RS11500	2342712..2342843	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T175104 WP_000482652.1 NZ_CP062413:2338114-2338221 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175104 NZ_CP081768:c294945-294529 [Escherichia coli]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAGTTTGAGCGGGTGCCGGATCTGGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175104 NZ_CP062413:c2338298-2338238 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin