Detailed information of TA system TA175100

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 216358..216538
• Replicon: chromosome
• Accession: NZ_CP062413
• Organism: Staphylococcus aureus strain NAS_AN_176

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF724_RS01420
• Protein ID: WP_001801861.1
• Coordinates: 216443..216538 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	216358..216415 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF724_RS01390	212067..212201	+	135	WP_001791797.1	hypothetical protein	-
IF724_RS01395	212365..213921	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
IF724_RS01400	213914..215143	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
IF724_RS01405	215685..216095	+	411	WP_001808705.1	IS21 family transposase	-
IF724_RS01410	216080..216241	+	162	Protein_242	transposase	-
IF724_RS01415	216219..216320	-	102	WP_001792025.1	hypothetical protein	-
-	216358..216415	+	58	-	-	Antitoxin
IF724_RS01420	216443..216538	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF724_RS01425	216683..217695	+	1013	Protein_245	IS3 family transposase	-
IF724_RS01430	217893..218465	-	573	WP_000414216.1	hypothetical protein	-
IF724_RS01435	218566..218907	-	342	WP_000627540.1	DUF3969 family protein	-
IF724_RS01440	218948..219574	-	627	WP_000669024.1	hypothetical protein	-
IF724_RS01445	219649..220644	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
IF724_RS01450	220725..221375	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	189525..240557	51032

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T175100 WP_001801861.1 NZ_CP062413:c216538-216443 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T175100 NZ_CP081767:4476424-4476801 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT175100 NZ_CP062413:216358-216415 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin