Detailed information of TA system TA175096

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 62525..62863
• Replicon: chromosome
• Accession: NZ_CP062413
• Organism: Staphylococcus aureus strain NAS_AN_176

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: IF724_RS00440
• Protein ID: WP_072353918.1
• Coordinates: 62525..62701 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	62689..62863 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF724_RS00420	57692..61474	+	3783	WP_000582132.1	phage tail spike protein	-
IF724_RS00425	61467..61619	+	153	WP_001000058.1	hypothetical protein	-
IF724_RS00430	61665..61952	+	288	WP_001262620.1	hypothetical protein	-
IF724_RS00435	62008..62382	+	375	WP_000340977.1	hypothetical protein	-
IF724_RS00440	62525..62701	+	177	WP_072353918.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	62689..62863	-	175	-	-	Antitoxin
IF724_RS00450	62913..63167	+	255	WP_000611512.1	phage holin	-
IF724_RS00455	63179..63934	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF724_RS00460	64125..64616	+	492	WP_000920038.1	staphylokinase	-
IF724_RS00465	65267..65602	+	336	Protein_92	SH3 domain-containing protein	-
IF724_RS00470	66113..66463	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF724_RS00475	66516..66776	-	261	WP_001791826.1	hypothetical protein	-
IF724_RS00480	67087..67266	-	180	WP_000669791.1	hypothetical protein	-
IF724_RS00485	67638..67835	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn / sak / scn	52..66463	66411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T175096 WP_072353918.1 NZ_CP062413:62525-62701 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T175096 NZ_CP081767:3901455-3901796 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT175096 NZ_CP062413:c62863-62689 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin