Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 37699..38113 Replicon chromosome
Accession NZ_CP062413
Organism Staphylococcus aureus strain NAS_AN_176

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF724_RS00270 Protein ID WP_001065046.1
Coordinates 37699..37950 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF724_RS00275 Protein ID WP_000028424.1
Coordinates 37940..38113 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF724_RS00230 (33356) 33356..34276 + 921 WP_000138475.1 recombinase RecT -
IF724_RS00235 (34357) 34357..34974 + 618 WP_072353921.1 MBL fold metallo-hydrolase -
IF724_RS00240 (34975) 34975..35445 + 471 WP_000934762.1 single-stranded DNA-binding protein -
IF724_RS00245 (35475) 35475..36368 + 894 WP_000148327.1 DnaD domain-containing protein -
IF724_RS00250 (36375) 36375..36593 + 219 WP_000338527.1 hypothetical protein -
IF724_RS00255 (36602) 36602..37057 + 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
IF724_RS00260 (37070) 37070..37438 + 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
IF724_RS00265 (37442) 37442..37684 + 243 WP_000131381.1 phi PVL orf 51-like protein -
IF724_RS00270 (37699) 37699..37950 + 252 WP_001065046.1 DUF1024 family protein Toxin
IF724_RS00275 (37940) 37940..38113 + 174 WP_000028424.1 hypothetical protein Antitoxin
IF724_RS00280 (38139) 38139..38396 + 258 WP_031866878.1 hypothetical protein -
IF724_RS00285 (38397) 38397..38558 + 162 WP_000889682.1 hypothetical protein -
IF724_RS00290 (38573) 38573..39106 + 534 WP_001061838.1 dUTPase -
IF724_RS00295 (39143) 39143..39388 + 246 WP_001282074.1 hypothetical protein -
IF724_RS00300 (39385) 39385..39591 + 207 WP_000195803.1 DUF1381 domain-containing protein -
IF724_RS00305 (39588) 39588..39974 + 387 WP_000592201.1 hypothetical protein -
IF724_RS00310 (39971) 39971..40120 + 150 WP_000595305.1 transcriptional activator RinB -
IF724_RS00315 (40279) 40279..40929 + 651 WP_001005262.1 hypothetical protein -
IF724_RS00320 (40929) 40929..41129 + 201 WP_000265041.1 DUF1514 family protein -
IF724_RS00325 (41152) 41152..41622 + 471 WP_000282758.1 hypothetical protein -
IF724_RS00330 (41737) 41737..42189 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
IF724_RS00335 (42205) 42205..42549 + 345 WP_000817289.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / scn / sak / scn 52..66463 66411


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T175095 WP_001065046.1 NZ_CP062413:37699-37950 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T175095 NZ_CP081767:3701371-3701589 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT175095 WP_000028424.1 NZ_CP062413:37940-38113 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT175095 NZ_CP081767:3700971-3701345 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References