Detailed information of TA system TA175078

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 183383..183563
• Replicon: chromosome
• Accession: NZ_CP062412
• Organism: Staphylococcus aureus strain NAS_AN_181

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF725_RS01135
• Protein ID: WP_001801861.1
• Coordinates: 183468..183563 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	183383..183440 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF725_RS01105	179734..180852	+	1119	WP_240100862.1	restriction endonuclease subunit S	-
IF725_RS01110	181500..181916	+	417	WP_020978241.1	DUF1433 domain-containing protein	-
IF725_RS01115	182222..182500	+	279	WP_001798632.1	DUF1433 domain-containing protein	-
IF725_RS01120	182522..182896	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF725_RS01125	183084..183266	+	183	Protein_187	transposase	-
IF725_RS01130	183244..183345	-	102	WP_001791232.1	hypothetical protein	-
-	183383..183440	+	58	-	-	Antitoxin
IF725_RS01135	183468..183563	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF725_RS01140	184014..184460	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF725_RS01145	185145..185528	+	384	WP_000070811.1	hypothetical protein	-
IF725_RS01150	185539..185715	+	177	WP_000375476.1	hypothetical protein	-
IF725_RS01155	186015..186643	+	629	Protein_193	ImmA/IrrE family metallo-endopeptidase	-
IF725_RS01160	186841..187413	-	573	WP_000414206.1	hypothetical protein	-
IF725_RS01165	187514..187855	-	342	WP_000627547.1	DUF3969 family protein	-
IF725_RS01170	187896..188522	-	627	WP_000669021.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	154487..220256	65769

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T175078 WP_001801861.1 NZ_CP062412:c183563-183468 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T175078 NZ_CP081764:45858-46274 [Escherichia coli]
ATGAAGAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGACGCGCCT
GGAGCAGGCAGTACTGCGCGGCCATCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCACCGCGCCACGTCCAGCTGGTTGACGCGTTCTGCGCACGCCTCGACGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGATGCGACCATTGAGATCAAGGTCGCACTGCGCCTCGCCGGCACGCCGATCGGACCGAACGACACGGCAATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTGCTGGTGACGAATAATACACGGGAGTTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT175078 NZ_CP062412:183383-183440 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin