Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2760872..2761286 Replicon chromosome
Accession NZ_CP062411
Organism Staphylococcus aureus strain NAS_AN_204

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF728_RS13780 Protein ID WP_001065046.1
Coordinates 2760872..2761123 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF728_RS13785 Protein ID WP_000028424.1
Coordinates 2761113..2761286 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF728_RS13740 (2756529) 2756529..2757449 + 921 WP_000138475.1 recombinase RecT -
IF728_RS13745 (2757530) 2757530..2758147 + 618 WP_072353921.1 MBL fold metallo-hydrolase -
IF728_RS13750 (2758148) 2758148..2758618 + 471 WP_000934762.1 single-stranded DNA-binding protein -
IF728_RS13755 (2758648) 2758648..2759541 + 894 WP_000148327.1 DnaD domain-containing protein -
IF728_RS13760 (2759548) 2759548..2759766 + 219 WP_000338527.1 hypothetical protein -
IF728_RS13765 (2759775) 2759775..2760230 + 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
IF728_RS13770 (2760243) 2760243..2760611 + 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
IF728_RS13775 (2760615) 2760615..2760857 + 243 WP_000131381.1 phi PVL orf 51-like protein -
IF728_RS13780 (2760872) 2760872..2761123 + 252 WP_001065046.1 DUF1024 family protein Toxin
IF728_RS13785 (2761113) 2761113..2761286 + 174 WP_000028424.1 hypothetical protein Antitoxin
IF728_RS13790 (2761315) 2761315..2761569 + 255 WP_223297745.1 hypothetical protein -
IF728_RS13795 (2761570) 2761570..2761731 + 162 WP_000889682.1 hypothetical protein -
IF728_RS13800 (2761746) 2761746..2762279 + 534 WP_001061838.1 dUTPase -
IF728_RS13805 (2762316) 2762316..2762561 + 246 WP_001282074.1 hypothetical protein -
IF728_RS13810 (2762558) 2762558..2762764 + 207 WP_000195803.1 DUF1381 domain-containing protein -
IF728_RS13815 (2762761) 2762761..2763147 + 387 WP_000592201.1 hypothetical protein -
IF728_RS13820 (2763144) 2763144..2763293 + 150 WP_000595305.1 transcriptional activator RinB -
IF728_RS13825 (2763452) 2763452..2764102 + 651 WP_001005262.1 hypothetical protein -
IF728_RS13830 (2764102) 2764102..2764302 + 201 WP_000265041.1 DUF1514 family protein -
IF728_RS13835 (2764325) 2764325..2764795 + 471 WP_000282758.1 hypothetical protein -
IF728_RS13840 (2764910) 2764910..2765362 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
IF728_RS13845 (2765378) 2765378..2765722 + 345 WP_000817289.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb 2735588..2766317 30729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T175073 WP_001065046.1 NZ_CP062411:2760872-2761123 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T175073 NZ_CP081762:4454928-4455305 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT175073 WP_000028424.1 NZ_CP062411:2761113-2761286 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT175073 NZ_CP081762:4454512-4454838 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References