Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2760872..2761286 | Replicon | chromosome |
| Accession | NZ_CP062411 | ||
| Organism | Staphylococcus aureus strain NAS_AN_204 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IF728_RS13780 | Protein ID | WP_001065046.1 |
| Coordinates | 2760872..2761123 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IF728_RS13785 | Protein ID | WP_000028424.1 |
| Coordinates | 2761113..2761286 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF728_RS13740 (2756529) | 2756529..2757449 | + | 921 | WP_000138475.1 | recombinase RecT | - |
| IF728_RS13745 (2757530) | 2757530..2758147 | + | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| IF728_RS13750 (2758148) | 2758148..2758618 | + | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| IF728_RS13755 (2758648) | 2758648..2759541 | + | 894 | WP_000148327.1 | DnaD domain-containing protein | - |
| IF728_RS13760 (2759548) | 2759548..2759766 | + | 219 | WP_000338527.1 | hypothetical protein | - |
| IF728_RS13765 (2759775) | 2759775..2760230 | + | 456 | WP_000401965.1 | RusA family crossover junction endodeoxyribonuclease | - |
| IF728_RS13770 (2760243) | 2760243..2760611 | + | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| IF728_RS13775 (2760615) | 2760615..2760857 | + | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| IF728_RS13780 (2760872) | 2760872..2761123 | + | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| IF728_RS13785 (2761113) | 2761113..2761286 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| IF728_RS13790 (2761315) | 2761315..2761569 | + | 255 | WP_223297745.1 | hypothetical protein | - |
| IF728_RS13795 (2761570) | 2761570..2761731 | + | 162 | WP_000889682.1 | hypothetical protein | - |
| IF728_RS13800 (2761746) | 2761746..2762279 | + | 534 | WP_001061838.1 | dUTPase | - |
| IF728_RS13805 (2762316) | 2762316..2762561 | + | 246 | WP_001282074.1 | hypothetical protein | - |
| IF728_RS13810 (2762558) | 2762558..2762764 | + | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| IF728_RS13815 (2762761) | 2762761..2763147 | + | 387 | WP_000592201.1 | hypothetical protein | - |
| IF728_RS13820 (2763144) | 2763144..2763293 | + | 150 | WP_000595305.1 | transcriptional activator RinB | - |
| IF728_RS13825 (2763452) | 2763452..2764102 | + | 651 | WP_001005262.1 | hypothetical protein | - |
| IF728_RS13830 (2764102) | 2764102..2764302 | + | 201 | WP_000265041.1 | DUF1514 family protein | - |
| IF728_RS13835 (2764325) | 2764325..2764795 | + | 471 | WP_000282758.1 | hypothetical protein | - |
| IF728_RS13840 (2764910) | 2764910..2765362 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| IF728_RS13845 (2765378) | 2765378..2765722 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL / hlb | 2735588..2766317 | 30729 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T175073 WP_001065046.1 NZ_CP062411:2760872-2761123 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T175073 NZ_CP081762:4454928-4455305 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT175073 WP_000028424.1 NZ_CP062411:2761113-2761286 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT175073 NZ_CP081762:4454512-4454838 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|