Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2352950..2353467 Replicon chromosome
Accession NZ_CP062411
Organism Staphylococcus aureus strain NAS_AN_204

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag IF728_RS11615 Protein ID WP_000113265.1
Coordinates 2353201..2353467 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF728_RS11610 Protein ID WP_000584499.1
Coordinates 2352950..2353201 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF728_RS11580 (2348648) 2348648..2349367 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF728_RS11585 (2349364) 2349364..2350095 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF728_RS11590 (2350192) 2350192..2351442 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
IF728_RS11595 (2351697) 2351697..2352059 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF728_RS11600 (2352078) 2352078..2352677 + 600 WP_000162810.1 DsbA family protein -
IF728_RS11605 (2352705) 2352705..2352785 + 81 WP_223197974.1 hypothetical protein -
IF728_RS11610 (2352950) 2352950..2353201 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF728_RS11615 (2353201) 2353201..2353467 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
IF728_RS11620 (2353502) 2353502..2353573 + 72 Protein_2259 hypothetical protein -
IF728_RS11625 (2353762) 2353762..2355309 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF728_RS11630 (2355495) 2355495..2355962 + 468 WP_000153347.1 SRPBCC domain-containing protein -
IF728_RS11635 (2356046) 2356046..2356228 + 183 WP_000230292.1 hypothetical protein -
IF728_RS11640 (2356445) 2356445..2357269 + 825 WP_000572038.1 formate/nitrite transporter family protein -
IF728_RS11645 (2357503) 2357503..2358039 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T175066 WP_000113265.1 NZ_CP062411:2353201-2353467 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T175066 NZ_CP081762:2937019-2937126 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT175066 WP_000584499.1 NZ_CP062411:2352950-2353201 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT175066 NZ_CP081762:c2936972-2936906 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References