Detailed information of TA system TA175051

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2630139..2630417
• Replicon: chromosome
• Accession: NZ_CP062410
• Organism: Staphylococcus aureus strain NAS_AN_205

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF729_RS13000
• Protein ID: WP_001802298.1
• Coordinates: 2630139..2630243 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2630239..2630417 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF729_RS12985	2626936..2627718	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IF729_RS12990	2627786..2628643	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
IF729_RS12995	2629301..2629459	-	159	WP_001792784.1	hypothetical protein	-
IF729_RS13000	2630139..2630243	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2630239..2630417	-	179	-	-	Antitoxin
IF729_RS13010	2630676..2631767	-	1092	WP_000495669.1	hypothetical protein	-
IF729_RS13015	2632033..2633010	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IF729_RS13020	2633012..2633332	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF729_RS13025	2633484..2634149	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175051 WP_001802298.1 NZ_CP062410:2630139-2630243 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175051 NZ_CP081745:c12465-12124 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT175051 NZ_CP062410:c2630417-2630239 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin