Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2364190..2364707 | Replicon | chromosome |
| Accession | NZ_CP062410 | ||
| Organism | Staphylococcus aureus strain NAS_AN_205 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | IF729_RS11615 | Protein ID | WP_000113265.1 |
| Coordinates | 2364441..2364707 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF729_RS11610 | Protein ID | WP_000584499.1 |
| Coordinates | 2364190..2364441 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF729_RS11580 (2359888) | 2359888..2360607 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| IF729_RS11585 (2360604) | 2360604..2361335 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IF729_RS11590 (2361432) | 2361432..2362682 | - | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF729_RS11595 (2362937) | 2362937..2363299 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF729_RS11600 (2363318) | 2363318..2363917 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| IF729_RS11605 (2363945) | 2363945..2364025 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| IF729_RS11610 (2364190) | 2364190..2364441 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF729_RS11615 (2364441) | 2364441..2364707 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF729_RS11620 (2364742) | 2364742..2364813 | + | 72 | Protein_2258 | hypothetical protein | - |
| IF729_RS11625 (2365002) | 2365002..2366549 | + | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF729_RS11630 (2366735) | 2366735..2367202 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| IF729_RS11635 (2367286) | 2367286..2367468 | + | 183 | WP_000230292.1 | hypothetical protein | - |
| IF729_RS11640 (2367685) | 2367685..2368509 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| IF729_RS11645 (2368743) | 2368743..2369279 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T175049 WP_000113265.1 NZ_CP062410:2364441-2364707 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T175049 NZ_CP081744:45857-46273 [Escherichia coli]
ATGAAGAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGACGCGCCT
GGAGCAGGCAGTACTGCGCGGCCATCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCACCGCGCCACGTCCAGCTGGTTGACGCGTTCTGCGCACGCCTCGACGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGATGCGACCATTGAGATCAAGGTCGCACTGCGCCTCGCCGGCACGCCGATCGGACCGAACGACACGGCAATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTGCTGGTGACGAATAATACACGGGAGTTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA
ATGAAGAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGACGCGCCT
GGAGCAGGCAGTACTGCGCGGCCATCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCACCGCGCCACGTCCAGCTGGTTGACGCGTTCTGCGCACGCCTCGACGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGATGCGACCATTGAGATCAAGGTCGCACTGCGCCTCGCCGGCACGCCGATCGGACCGAACGACACGGCAATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTGCTGGTGACGAATAATACACGGGAGTTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT175049 WP_000584499.1 NZ_CP062410:2364190-2364441 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT175049 NZ_CP081744:45630-45860 [Escherichia coli]
ATGCGCACAGTTTCTATTTTCAAAAACGGCAACAACCGCGCCATTCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCAACCTGGGGTTCGTTCGCGCAGCTCG
AAAAAGCTGACCCTGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAACTATGA
ATGCGCACAGTTTCTATTTTCAAAAACGGCAACAACCGCGCCATTCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCAACCTGGGGTTCGTTCGCGCAGCTCG
AAAAAGCTGACCCTGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAACTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|