Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2322782..2323299 | Replicon | chromosome |
| Accession | NZ_CP062409 | ||
| Organism | Staphylococcus aureus strain NAS_AN_239 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | IF734_RS11315 | Protein ID | WP_000113265.1 |
| Coordinates | 2323033..2323299 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF734_RS11310 | Protein ID | WP_000584499.1 |
| Coordinates | 2322782..2323033 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF734_RS11280 (2318480) | 2318480..2319199 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| IF734_RS11285 (2319196) | 2319196..2319927 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IF734_RS11290 (2320024) | 2320024..2321274 | - | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF734_RS11295 (2321529) | 2321529..2321891 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF734_RS11300 (2321910) | 2321910..2322509 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| IF734_RS11305 (2322537) | 2322537..2322617 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| IF734_RS11310 (2322782) | 2322782..2323033 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF734_RS11315 (2323033) | 2323033..2323299 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF734_RS11320 (2323334) | 2323334..2323405 | + | 72 | Protein_2200 | hypothetical protein | - |
| IF734_RS11325 (2323594) | 2323594..2325141 | + | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF734_RS11330 (2325327) | 2325327..2325794 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| IF734_RS11335 (2325878) | 2325878..2326060 | + | 183 | WP_000230292.1 | hypothetical protein | - |
| IF734_RS11340 (2326277) | 2326277..2327101 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| IF734_RS11345 (2327335) | 2327335..2327871 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T175031 WP_000113265.1 NZ_CP062409:2323033-2323299 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T175031 NZ_CP081742:1164035-1164346 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT175031 WP_000584499.1 NZ_CP062409:2322782-2323033 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT175031 NZ_CP081742:1164343-1164762 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|