Detailed information of TA system TA175015

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2673164..2673426
• Replicon: chromosome
• Accession: NZ_CP062408
• Organism: Staphylococcus aureus strain NAS_AN_247

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF735_RS13235
• Protein ID: WP_001802298.1
• Coordinates: 2673164..2673268 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2673263..2673426 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF735_RS13220	2669961..2670743	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF735_RS13225	2670811..2671668	+	858	WP_000370928.1	HAD family hydrolase	-
IF735_RS13230	2672326..2672484	-	159	WP_001792784.1	hypothetical protein	-
IF735_RS13235	2673164..2673268	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2673263..2673426	-	164	-	-	Antitoxin
IF735_RS13245	2673710..2674801	-	1092	WP_000495681.1	hypothetical protein	-
IF735_RS13250	2675067..2676047	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF735_RS13255	2676049..2676369	-	321	WP_000003756.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF735_RS13260	2676521..2677186	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T175015 WP_001802298.1 NZ_CP062408:2673164-2673268 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T175015 NZ_CP081724:c4298386-4298036 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT175015 NZ_CP062408:c2673426-2673263 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin