Detailed information of TA system TA175012

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2391871..2392055
• Replicon: chromosome
• Accession: NZ_CP062408
• Organism: Staphylococcus aureus strain NAS_AN_247

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF735_RS11765
• Protein ID: WP_000482650.1
• Coordinates: 2391871..2391978 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2391995..2392055 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF735_RS11740	2387243..2387716	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF735_RS11745	2387839..2389050	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF735_RS11750	2389232..2389891	-	660	WP_000831298.1	membrane protein	-
IF735_RS11755	2389951..2391093	-	1143	WP_001176863.1	glycerate kinase	-
IF735_RS11760	2391351..2391737	+	387	WP_000779358.1	flippase GtxA	-
IF735_RS11765	2391871..2391978	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2391995..2392055	-	61	-	-	Antitoxin
IF735_RS11770	2392626..2394389	+	1764	WP_031911008.1	ABC transporter ATP-binding protein	-
IF735_RS11775	2394414..2396147	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF735_RS11780	2396378..2396545	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T175012 WP_000482650.1 NZ_CP062408:2391871-2391978 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175012 NZ_CP081724:3866635-3866976 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175012 NZ_CP062408:c2392055-2391995 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin