Detailed information of TA system TA175008

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 181593..181773
• Replicon: chromosome
• Accession: NZ_CP062408
• Organism: Staphylococcus aureus strain NAS_AN_247

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF735_RS01135
• Protein ID: WP_001801861.1
• Coordinates: 181678..181773 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	181593..181650 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF735_RS01105	177944..179062	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
IF735_RS01110	179710..180153	+	444	WP_000742594.1	DUF1433 domain-containing protein	-
IF735_RS01115	180432..180710	+	279	WP_001798632.1	DUF1433 domain-containing protein	-
IF735_RS01120	180732..181106	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF735_RS01125	181294..181476	+	183	Protein_186	transposase	-
IF735_RS01130	181454..181555	-	102	WP_001791232.1	hypothetical protein	-
-	181593..181650	+	58	-	-	Antitoxin
IF735_RS01135	181678..181773	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF735_RS01140	182224..182670	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF735_RS01145	183355..183738	+	384	WP_000070811.1	hypothetical protein	-
IF735_RS01150	183749..183925	+	177	WP_000375476.1	hypothetical protein	-
IF735_RS01155	184225..184853	+	629	Protein_192	ImmA/IrrE family metallo-endopeptidase	-
IF735_RS01160	185051..185623	-	573	WP_000414206.1	hypothetical protein	-
IF735_RS01165	185724..186065	-	342	WP_240053176.1	DUF3969 family protein	-
IF735_RS01170	186106..186732	-	627	WP_000669021.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	152698..189290	36592

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T175008 WP_001801861.1 NZ_CP062408:c181773-181678 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T175008 NZ_CP081724:c2631986-2631810 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT175008 NZ_CP062408:181593-181650 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin