Detailed information of TA system TA175004

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18898..19236
• Replicon: chromosome
• Accession: NZ_CP062408
• Organism: Staphylococcus aureus strain NAS_AN_247

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: IF735_RS00105
• Protein ID: WP_072490424.1
• Coordinates: 18898..19074 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19062..19236 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF735_RS00085	14065..17847	+	3783	WP_000582177.1	phage tail spike protein	-
IF735_RS00090	17840..17992	+	153	WP_001000058.1	hypothetical protein	-
IF735_RS00095	18038..18325	+	288	WP_001262620.1	hypothetical protein	-
IF735_RS00100	18381..18755	+	375	WP_000340977.1	hypothetical protein	-
IF735_RS00105	18898..19074	+	177	WP_072490424.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19062..19236	-	175	-	-	Antitoxin
IF735_RS00115	19286..19540	+	255	WP_000611512.1	phage holin	-
IF735_RS00120	19552..20307	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF735_RS00125	20498..20989	+	492	WP_000920041.1	staphylokinase	-
IF735_RS00130	21640..21974	+	335	Protein_25	SH3 domain-containing protein	-
IF735_RS00135	22067..22516	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
IF735_RS00140	23199..23549	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
IF735_RS00145	23602..23862	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1..23549	23548

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6921.51 Da
• Isoelectric Point: 10.3583

>T175004 WP_072490424.1 NZ_CP062408:18898-19074 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIDLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T175004 NZ_CP081724:1961247-1961498 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT175004 NZ_CP062408:c19236-19062 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin