Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2801981..2802404 Replicon chromosome
Accession NZ_CP062407
Organism Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag IF751_RS13795 Protein ID WP_001065110.1
Coordinates 2801981..2802232 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag IF751_RS13800 Protein ID WP_000028425.1
Coordinates 2802222..2802404 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF751_RS13760 (2798073) 2798073..2798630 + 558 WP_000645048.1 DUF2815 family protein -
IF751_RS13765 (2798698) 2798698..2800650 + 1953 WP_001802096.1 DNA polymerase -
IF751_RS13770 (2800663) 2800663..2800848 + 186 WP_001164629.1 DUF3113 family protein -
IF751_RS13775 (2800848) 2800848..2801249 + 402 WP_000113974.1 PVL family protein -
IF751_RS13780 (2801249) 2801249..2801506 + 258 WP_000022730.1 DUF3310 domain-containing protein -
IF751_RS13785 (2801509) 2801509..2801709 + 201 WP_000235324.1 hypothetical protein -
IF751_RS13790 (2801724) 2801724..2801966 + 243 WP_000132193.1 SAV1978 family virulence-associated passenger protein -
IF751_RS13795 (2801981) 2801981..2802232 + 252 WP_001065110.1 DUF1024 family protein Toxin
IF751_RS13800 (2802222) 2802222..2802404 + 183 WP_000028425.1 hypothetical protein Antitoxin
IF751_RS13805 (2802397) 2802397..2802933 + 537 WP_000185703.1 dUTPase -
IF751_RS13810 (2802970) 2802970..2803206 + 237 WP_000195806.1 DUF1381 domain-containing protein -
IF751_RS13815 (2803231) 2803231..2803467 + 237 WP_000483477.1 hypothetical protein -
IF751_RS13820 (2803460) 2803460..2803612 + 153 WP_000595237.1 transcriptional activator RinB -
IF751_RS13825 (2803680) 2803680..2803880 + 201 WP_000265258.1 DUF1514 family protein -
IF751_RS13830 (2803933) 2803933..2806380 + 2448 WP_000884879.1 virulence-associated E family protein -
IF751_RS13835 (2806483) 2806483..2806587 - 105 WP_015978074.1 hypothetical protein -
IF751_RS13840 (2806721) 2806721..2807011 + 291 WP_000665205.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T175003 WP_001065110.1 NZ_CP062407:2801981-2802232 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T175003 NZ_CP081724:1164032-1164343 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT175003 WP_000028425.1 NZ_CP062407:2802222-2802404 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT175003 NZ_CP081724:1164340-1164759 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References