Detailed information of TA system TA175000

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2794794..2795373
• Replicon: chromosome
• Accession: NZ_CP062407
• Organism: Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: IF751_RS13720
• Protein ID: WP_001025401.1
• Coordinates: 2794794..2795039 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2795008..2795373 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF751_RS13670 (2791043)	2791043..2791657	+	615	WP_000191466.1	hypothetical protein	-
IF751_RS13675 (2791654)	2791654..2791800	-	147	WP_001794606.1	hypothetical protein	-
IF751_RS13680 (2791837)	2791837..2792019	-	183	WP_000705240.1	hypothetical protein	-
IF751_RS13685 (2792090)	2792090..2792776	-	687	WP_000177667.1	XRE family transcriptional regulator	-
IF751_RS13690 (2792973)	2792973..2793185	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
IF751_RS13695 (2793233)	2793233..2793676	+	444	WP_000435357.1	hypothetical protein	-
IF751_RS13700 (2793691)	2793691..2793840	+	150	WP_000771849.1	hypothetical protein	-
IF751_RS13705 (2793881)	2793881..2794093	-	213	WP_000362643.1	hypothetical protein	-
IF751_RS13710 (2794163)	2794163..2794360	+	198	WP_001148860.1	hypothetical protein	-
IF751_RS13715 (2794347)	2794347..2794727	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
IF751_RS13720 (2794794)	2794794..2795039	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
IF751_RS13725 (2795008)	2795008..2795373	-	366	WP_001128433.1	hypothetical protein	Antitoxin
IF751_RS13730 (2795428)	2795428..2795643	+	216	WP_001097552.1	hypothetical protein	-
IF751_RS13735 (2795668)	2795668..2795931	+	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
IF751_RS13740 (2795944)	2795944..2796105	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
IF751_RS13745 (2796184)	2796184..2796507	+	324	WP_000174998.1	hypothetical protein	-
IF751_RS13750 (2796522)	2796522..2796884	+	363	WP_000985972.1	hypothetical protein	-
IF751_RS13755 (2796881)	2796881..2798047	+	1167	WP_000762530.1	DUF2800 domain-containing protein	-
IF751_RS13760 (2798073)	2798073..2798630	+	558	WP_000645048.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T175000 WP_001025401.1 NZ_CP062407:2794794-2795039 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T175000 NZ_CP081724:819736-820032 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT175000 NZ_CP062407:c2795373-2795008 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin