Detailed information of TA system TA174998

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2463282..2463462
• Replicon: chromosome
• Accession: NZ_CP062407
• Organism: Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF751_RS12050
• Protein ID: WP_001801861.1
• Coordinates: 2463367..2463462 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2463282..2463339 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF751_RS12030	2461097..2461540	+	444	WP_000747798.1	DUF1433 domain-containing protein	-
IF751_RS12035	2461540..2461983	+	444	WP_000731420.1	DUF1433 domain-containing protein	-
IF751_RS12040	2461983..2462426	+	444	WP_000728661.1	DUF1433 domain-containing protein	-
IF751_RS12045	2463180..2463244	-	65	Protein_2329	hypothetical protein	-
-	2463282..2463339	+	58	-	-	Antitoxin
IF751_RS12050	2463367..2463462	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF751_RS12055	2463607..2463843	+	237	WP_000251969.1	IS3 family transposase	-
IF751_RS12060	2464032..2464190	+	159	WP_229375660.1	hypothetical protein	-
IF751_RS12065	2464217..2464539	+	323	Protein_2333	hypothetical protein	-
IF751_RS12070	2464550..2464726	+	177	WP_000375478.1	hypothetical protein	-
IF751_RS12075	2464728..2464913	+	186	WP_000809860.1	hypothetical protein	-
IF751_RS12080	2465243..2465815	-	573	WP_000414218.1	hypothetical protein	-
IF751_RS12085	2465916..2466257	-	342	WP_000627534.1	DUF3969 family protein	-
IF751_RS12090	2466298..2466924	-	627	WP_000669045.1	hypothetical protein	-
IF751_RS12095	2467000..2467995	-	996	WP_020977362.1	DUF4352 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2463607..2463843	236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174998 WP_001801861.1 NZ_CP062407:c2463462-2463367 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174998 NZ_CP081724:704536-704850 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174998 NZ_CP062407:2463282-2463339 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin