Detailed information of TA system TA174990

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2149739..2150002
• Replicon: chromosome
• Accession: NZ_CP062407
• Organism: Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF751_RS10295
• Protein ID: WP_001802298.1
• Coordinates: 2149739..2149843 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2149838..2150002 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF751_RS10275	2145709..2146845	+	1137	Protein_2017	SAP domain-containing protein	-
IF751_RS10280	2146981..2147742	-	762	WP_240052993.1	IS21-like element helper ATPase IstB	-
IF751_RS10285	2147735..2149027	-	1293	WP_020977460.1	IS21 family transposase	-
IF751_RS10290	2149075..2149578	+	504	Protein_2020	recombinase family protein	-
IF751_RS10295	2149739..2149843	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2149838..2150002	-	165	-	-	Antitoxin
IF751_RS10305	2150292..2151383	-	1092	WP_020977458.1	hypothetical protein	-
IF751_RS10310	2151649..2152626	-	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
IF751_RS10315	2152628..2152948	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF751_RS10320	2153100..2153765	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2146981..2147742	761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174990 WP_001802298.1 NZ_CP062407:2149739-2149843 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174990 NZ_CP081720:77882-78298 [Escherichia coli]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTGCCGGATCTGGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT174990 NZ_CP062407:c2150002-2149838 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin