Detailed information of TA system TA174989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1882126..1882643
• Replicon: chromosome
• Accession: NZ_CP062407
• Organism: Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: IF751_RS08910
• Protein ID: WP_000113263.1
• Coordinates: 1882377..1882643 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: IF751_RS08905
• Protein ID: WP_000584499.1
• Coordinates: 1882126..1882377 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF751_RS08875 (1877825)	1877825..1878544	+	720	WP_000479576.1	amino acid ABC transporter permease	-
IF751_RS08880 (1878541)	1878541..1879272	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
IF751_RS08885 (1879369)	1879369..1880619	-	1251	WP_064133576.1	FemA/FemB family glycyltransferase FmhA	-
IF751_RS08890 (1880874)	1880874..1881236	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
IF751_RS08895 (1881255)	1881255..1881854	+	600	WP_020977542.1	DsbA family protein	-
IF751_RS08900 (1881861)	1881861..1881953	+	93	Protein_1752	hypothetical protein	-
IF751_RS08905 (1882126)	1882126..1882377	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF751_RS08910 (1882377)	1882377..1882643	+	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
IF751_RS08915 (1882660)	1882660..1882758	+	99	WP_224089274.1	hypothetical protein	-
IF751_RS08920 (1882937)	1882937..1884484	+	1548	WP_020977541.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
IF751_RS08925 (1884670)	1884670..1885137	+	468	WP_020977540.1	SRPBCC domain-containing protein	-
IF751_RS08930 (1885224)	1885224..1885406	+	183	WP_000079140.1	hypothetical protein	-
IF751_RS08935 (1885609)	1885609..1886433	+	825	WP_000594640.1	formate/nitrite transporter family protein	-
IF751_RS08940 (1886903)	1886903..1887439	+	537	WP_020977539.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T174989 WP_000113263.1 NZ_CP062407:1882377-1882643 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T174989 NZ_CP081719:c4436302-4436129 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT174989 WP_000584499.1 NZ_CP062407:1882126-1882377 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT174989 NZ_CP081719:c4436626-4436330 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60