Detailed information of TA system TA174987

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1857163..1857347
• Replicon: chromosome
• Accession: NZ_CP062407
• Organism: Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF751_RS08775
• Protein ID: WP_000482647.1
• Coordinates: 1857163..1857270 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1857287..1857347 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF751_RS08750	1852524..1852997	+	474	WP_020977553.1	GyrI-like domain-containing protein	-
IF751_RS08755	1853120..1854331	-	1212	WP_001191921.1	multidrug effflux MFS transporter	-
IF751_RS08760	1854514..1855173	-	660	WP_000831298.1	membrane protein	-
IF751_RS08765	1855233..1856375	-	1143	WP_001176863.1	glycerate kinase	-
IF751_RS08770	1856643..1857029	+	387	WP_000779353.1	flippase GtxA	-
IF751_RS08775	1857163..1857270	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1857287..1857347	-	61	-	-	Antitoxin
IF751_RS08780	1857918..1859681	+	1764	WP_001064822.1	ABC transporter ATP-binding protein	-
IF751_RS08785	1859706..1861439	+	1734	WP_020977552.1	ABC transporter ATP-binding protein	-
IF751_RS08790	1861670..1861837	+	168	WP_001789205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174987 WP_000482647.1 NZ_CP062407:1857163-1857270 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174987 NZ_CP081719:c4298368-4298018 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174987 NZ_CP062407:c1857347-1857287 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin