Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1825511..1826034 Replicon chromosome
Accession NZ_CP062407
Organism Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag IF751_RS08635 Protein ID WP_042908766.1
Coordinates 1825768..1826034 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag IF751_RS08630 Protein ID WP_020977565.1
Coordinates 1825511..1825768 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF751_RS08610 (1820584) 1820584..1821777 + 1194 WP_000675402.1 MFS transporter -
IF751_RS08615 (1822001) 1822001..1822750 - 750 WP_020977566.1 CPBP family lipoprotein N-acylation protein LnsB -
IF751_RS08620 (1822945) 1822945..1824522 + 1578 WP_000143488.1 FMN-binding glutamate synthase family protein -
IF751_RS08625 (1824697) 1824697..1825152 - 456 WP_000732085.1 YehR family lipoprotein -
IF751_RS08630 (1825511) 1825511..1825768 + 258 WP_020977565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF751_RS08635 (1825768) 1825768..1826034 + 267 WP_042908766.1 Txe/YoeB family addiction module toxin Toxin
IF751_RS08640 (1826390) 1826390..1827466 + 1077 WP_001076676.1 M42 family metallopeptidase -
IF751_RS08645 (1827809) 1827809..1828471 + 663 WP_020977564.1 ATP-binding cassette domain-containing protein -
IF751_RS08650 (1828464) 1828464..1829240 + 777 WP_020977563.1 iron export ABC transporter permease subunit FetB -
IF751_RS08655 (1829636) 1829636..1830823 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(28-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10638.34 Da        Isoelectric Point: 10.0798

>T174986 WP_042908766.1 NZ_CP062407:1825768-1826034 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNDPCKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174986 NZ_CP081719:c4222760-4222473 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT174986 WP_020977565.1 NZ_CP062407:1825511-1825768 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174986 NZ_CP081719:c4222486-4222184 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References