Detailed information of TA system TA174984

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 863537..863836
• Replicon: chromosome
• Accession: NZ_CP062407
• Organism: Staphylococcus aureus strain NAS_NP_181

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF751_RS04115
• Protein ID: WP_011447039.1
• Coordinates: 863660..863836 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	863537..863592 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF751_RS04080	859181..859531	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF751_RS04085	860216..860665	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
IF751_RS04090	860760..861095	-	336	Protein_813	SH3 domain-containing protein	-
IF751_RS04095	861745..862236	-	492	WP_000920037.1	staphylokinase	-
IF751_RS04100	862427..863182	-	756	WP_000861038.1	CHAP domain-containing protein	-
IF751_RS04105	863194..863448	-	255	WP_000611512.1	phage holin	-
IF751_RS04110	863500..863607	+	108	WP_001791821.1	hypothetical protein	-
-	863529..863668	+	140	NuclAT_0	-	-
-	863529..863668	+	140	NuclAT_0	-	-
-	863529..863668	+	140	NuclAT_0	-	-
-	863529..863668	+	140	NuclAT_0	-	-
-	863537..863592	+	56	-	-	Antitoxin
IF751_RS04115	863660..863836	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
IF751_RS04120	863986..864282	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
IF751_RS04125	864340..864627	-	288	WP_001040261.1	hypothetical protein	-
IF751_RS04130	864674..864826	-	153	WP_001153681.1	hypothetical protein	-
IF751_RS04135	864816..868601	-	3786	WP_020977044.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak	853845..882895	29050
	-	flank	IS/Tn	-	-	857253..858899	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174984 WP_011447039.1 NZ_CP062407:c863836-863660 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174984 NZ_CP081719:3866618-3866959 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT174984 NZ_CP062407:863537-863592 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin