Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-MW1433/- |
| Location | 863529..863836 | Replicon | chromosome |
| Accession | NZ_CP062407 | ||
| Organism | Staphylococcus aureus strain NAS_NP_181 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | IF751_RS04115 | Protein ID | WP_011447039.1 |
| Coordinates | 863660..863836 (-) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 863529..863668 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF751_RS04080 (859181) | 859181..859531 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| IF751_RS04085 (860216) | 860216..860665 | + | 450 | WP_000727649.1 | chemotaxis-inhibiting protein CHIPS | - |
| IF751_RS04090 (860760) | 860760..861095 | - | 336 | Protein_813 | SH3 domain-containing protein | - |
| IF751_RS04095 (861745) | 861745..862236 | - | 492 | WP_000920037.1 | staphylokinase | - |
| IF751_RS04100 (862427) | 862427..863182 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| IF751_RS04105 (863194) | 863194..863448 | - | 255 | WP_000611512.1 | phage holin | - |
| IF751_RS04110 (863500) | 863500..863607 | + | 108 | WP_001791821.1 | hypothetical protein | - |
| - (863529) | 863529..863668 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (863529) | 863529..863668 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (863529) | 863529..863668 | + | 140 | NuclAT_0 | - | Antitoxin |
| - (863529) | 863529..863668 | + | 140 | NuclAT_0 | - | Antitoxin |
| IF751_RS04115 (863660) | 863660..863836 | - | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| IF751_RS04120 (863986) | 863986..864282 | - | 297 | WP_000539688.1 | DUF2951 domain-containing protein | - |
| IF751_RS04125 (864340) | 864340..864627 | - | 288 | WP_001040261.1 | hypothetical protein | - |
| IF751_RS04130 (864674) | 864674..864826 | - | 153 | WP_001153681.1 | hypothetical protein | - |
| IF751_RS04135 (864816) | 864816..868601 | - | 3786 | WP_020977044.1 | phage tail spike protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak | 853845..882895 | 29050 | |
| - | flank | IS/Tn | - | - | 857253..858899 | 1646 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T174983 WP_011447039.1 NZ_CP062407:c863836-863660 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T174983 NZ_CP081719:3668039-3668257 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA
Antitoxin
Download Length: 140 bp
>AT174983 NZ_CP062407:863529-863668 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
