Detailed information of TA system TA174976

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2565316..2565578
• Replicon: chromosome
• Accession: NZ_CP062406
• Organism: Staphylococcus aureus strain NAS_NP_198

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF753_RS12545
• Protein ID: WP_001802298.1
• Coordinates: 2565316..2565420 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2565415..2565578 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF753_RS12530	2562113..2562895	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IF753_RS12535	2562963..2563820	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
IF753_RS12540	2564478..2564636	-	159	WP_001792784.1	hypothetical protein	-
IF753_RS12545	2565316..2565420	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2565415..2565578	-	164	-	-	Antitoxin
IF753_RS12555	2565853..2566944	-	1092	WP_000495669.1	hypothetical protein	-
IF753_RS12560	2567210..2568187	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IF753_RS12565	2568189..2568509	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF753_RS12570	2568661..2569326	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174976 WP_001802298.1 NZ_CP062406:2565316-2565420 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174976 NZ_CP081719:1961249-1961500 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT174976 NZ_CP062406:c2565578-2565415 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin