Detailed information of TA system TA174973

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2274335..2274519
• Replicon: chromosome
• Accession: NZ_CP062406
• Organism: Staphylococcus aureus strain NAS_NP_198

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF753_RS11025
• Protein ID: WP_000482652.1
• Coordinates: 2274335..2274442 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2274459..2274519 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF753_RS11000	2269697..2270170	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
IF753_RS11005	2270293..2271504	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF753_RS11010	2271686..2272345	-	660	WP_000831298.1	membrane protein	-
IF753_RS11015	2272405..2273547	-	1143	WP_001176863.1	glycerate kinase	-
IF753_RS11020	2273815..2274201	+	387	WP_000779360.1	flippase GtxA	-
IF753_RS11025	2274335..2274442	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2274459..2274519	-	61	-	-	Antitoxin
IF753_RS11030	2275145..2276908	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
IF753_RS11035	2276933..2278666	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
IF753_RS11040	2278933..2279064	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174973 WP_000482652.1 NZ_CP062406:2274335-2274442 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174973 NZ_CP081719:928604-929011 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174973 NZ_CP062406:c2274519-2274459 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin