Detailed information of TA system TA174969

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 176192..176372
• Replicon: chromosome
• Accession: NZ_CP062406
• Organism: Staphylococcus aureus strain NAS_NP_198

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF753_RS01105
• Protein ID: WP_001801861.1
• Coordinates: 176277..176372 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	176192..176249 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF753_RS01075	171901..172035	+	135	WP_001791797.1	hypothetical protein	-
IF753_RS01080	172199..173755	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
IF753_RS01085	173748..174977	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
IF753_RS01090	175519..175929	+	411	WP_001808705.1	IS21 family transposase	-
IF753_RS01095	175914..176075	+	162	Protein_180	transposase	-
IF753_RS01100	176053..176154	-	102	WP_001792025.1	hypothetical protein	-
-	176192..176249	+	58	-	-	Antitoxin
IF753_RS01105	176277..176372	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF753_RS01110	176517..177529	+	1013	Protein_183	IS3 family transposase	-
IF753_RS01115	177727..178299	-	573	WP_000414216.1	hypothetical protein	-
IF753_RS01120	178400..178741	-	342	WP_000627540.1	DUF3969 family protein	-
IF753_RS01125	178782..179408	-	627	WP_000669024.1	hypothetical protein	-
IF753_RS01130	179483..180478	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
IF753_RS01135	180559..181209	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	149360..200390	51030

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174969 WP_001801861.1 NZ_CP062406:c176372-176277 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174969 NZ_CP081719:c661625-661161 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGATGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174969 NZ_CP062406:176192-176249 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin