Detailed information of TA system TA174965

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20152..20490
• Replicon: chromosome
• Accession: NZ_CP062406
• Organism: Staphylococcus aureus strain NAS_NP_198

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF753_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20152..20328 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20316..20490 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF753_RS00085	17840..17992	+	153	WP_001000058.1	hypothetical protein	-
IF753_RS00090	18038..18325	+	288	WP_001262621.1	hypothetical protein	-
IF753_RS00095	18381..18755	+	375	WP_000340977.1	hypothetical protein	-
IF753_RS00100	19167..19949	+	783	WP_000034846.1	staphylococcal enterotoxin type P	-
IF753_RS00105	20152..20328	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20316..20490	-	175	-	-	Antitoxin
IF753_RS00115	20540..20794	+	255	WP_000611512.1	phage holin	-
IF753_RS00120	20806..21561	+	756	WP_000861026.1	CHAP domain-containing protein	-
IF753_RS00125	21752..22243	+	492	WP_000920042.1	staphylokinase	-
IF753_RS00130	22890..23224	+	335	Protein_26	SH3 domain-containing protein	-
IF753_RS00135	23319..23768	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
IF753_RS00140	24451..24801	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
IF753_RS00145	24854..25114	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	see / sak / chp / scn	1..24801	24800

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174965 WP_011447039.1 NZ_CP062406:20152-20328 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174965 NZ_CP081715:41103-41519 [Escherichia coli]
ATGAAGAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGACGCGCCT
GGAGCAGGCAGTACTGCGCGGCCATCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCACCGCGCCACGTCCAGCTGGTTGACGCGTTCTGCGCACGCCTCGACGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGATGCGACCATTGAGATCAAGGTCGCACTGCGCCTCGCCGGCACGCCGATCGGACCGAACGACACGGCAATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTGCTGGTGACGAATAATACACGGGAGTTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174965 NZ_CP062406:c20490-20316 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin