Detailed information of TA system TA174963

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2204033..2204217
• Replicon: chromosome
• Accession: NZ_CP062405
• Organism: Staphylococcus aureus strain NAS_NP_209

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF754_RS11255
• Protein ID: WP_000482647.1
• Coordinates: 2204110..2204217 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2204033..2204093 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF754_RS11240	2199543..2199710	-	168	Protein_2171	hypothetical protein	-
IF754_RS11245	2199941..2201674	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
IF754_RS11250	2201699..2203462	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	2204033..2204093	+	61	-	-	Antitoxin
IF754_RS11255	2204110..2204217	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF754_RS11260	2204351..2204737	-	387	WP_000779351.1	flippase GtxA	-
IF754_RS11265	2205005..2206147	+	1143	WP_001176855.1	glycerate kinase	-
IF754_RS11270	2206207..2206866	+	660	WP_000831298.1	membrane protein	-
IF754_RS11275	2207048..2208259	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
IF754_RS11280	2208382..2208855	-	474	WP_224212098.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174963 WP_000482647.1 NZ_CP062405:c2204217-2204110 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174963 NZ_CP081714:c54626-54210 [Escherichia coli]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTGCCGGATCTGGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174963 NZ_CP062405:2204033-2204093 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin