Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2178801..2179318 | Replicon | chromosome |
| Accession | NZ_CP062405 | ||
| Organism | Staphylococcus aureus strain NAS_NP_209 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A170NWK0 |
| Locus tag | IF754_RS11120 | Protein ID | WP_000251928.1 |
| Coordinates | 2178801..2179067 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A166LMC5 |
| Locus tag | IF754_RS11125 | Protein ID | WP_000584497.1 |
| Coordinates | 2179067..2179318 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF754_RS11095 (2174009) | 2174009..2174545 | - | 537 | WP_000024292.1 | GNAT family N-acetyltransferase | - |
| IF754_RS11100 (2175013) | 2175013..2175837 | - | 825 | WP_000594640.1 | formate/nitrite transporter family protein | - |
| IF754_RS11105 (2176040) | 2176040..2176222 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| IF754_RS11110 (2176308) | 2176308..2176775 | - | 468 | WP_000153340.1 | SRPBCC domain-containing protein | - |
| IF754_RS11115 (2176961) | 2176961..2178508 | - | 1548 | WP_000727771.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF754_RS11120 (2178801) | 2178801..2179067 | - | 267 | WP_000251928.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF754_RS11125 (2179067) | 2179067..2179318 | - | 252 | WP_000584497.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF754_RS11130 (2179482) | 2179482..2179582 | - | 101 | Protein_2149 | hypothetical protein | - |
| IF754_RS11135 (2179589) | 2179589..2180188 | - | 600 | WP_000162804.1 | DsbA family protein | - |
| IF754_RS11140 (2180207) | 2180207..2180569 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF754_RS11145 (2180824) | 2180824..2182074 | + | 1251 | WP_001012237.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF754_RS11150 (2182171) | 2182171..2182902 | - | 732 | WP_000615467.1 | amino acid ABC transporter ATP-binding protein | - |
| IF754_RS11155 (2182899) | 2182899..2183618 | - | 720 | WP_000479573.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10465.06 Da Isoelectric Point: 10.1628
>T174962 WP_000251928.1 NZ_CP062405:c2179067-2178801 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174962 NZ_CP081714:29953-30264 [Escherichia coli]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9401.54 Da Isoelectric Point: 4.3407
>AT174962 WP_000584497.1 NZ_CP062405:c2179318-2179067 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
Download Length: 252 bp
>AT174962 NZ_CP081714:30261-30680 [Escherichia coli]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTTCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTTCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A170NWK0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A166LMC5 |