Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2178801..2179318 Replicon chromosome
Accession NZ_CP062405
Organism Staphylococcus aureus strain NAS_NP_209

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag IF754_RS11120 Protein ID WP_000251928.1
Coordinates 2178801..2179067 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag IF754_RS11125 Protein ID WP_000584497.1
Coordinates 2179067..2179318 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF754_RS11095 (2174009) 2174009..2174545 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
IF754_RS11100 (2175013) 2175013..2175837 - 825 WP_000594640.1 formate/nitrite transporter family protein -
IF754_RS11105 (2176040) 2176040..2176222 - 183 WP_000079140.1 hypothetical protein -
IF754_RS11110 (2176308) 2176308..2176775 - 468 WP_000153340.1 SRPBCC domain-containing protein -
IF754_RS11115 (2176961) 2176961..2178508 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF754_RS11120 (2178801) 2178801..2179067 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
IF754_RS11125 (2179067) 2179067..2179318 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF754_RS11130 (2179482) 2179482..2179582 - 101 Protein_2149 hypothetical protein -
IF754_RS11135 (2179589) 2179589..2180188 - 600 WP_000162804.1 DsbA family protein -
IF754_RS11140 (2180207) 2180207..2180569 - 363 WP_000819843.1 DUF4467 domain-containing protein -
IF754_RS11145 (2180824) 2180824..2182074 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
IF754_RS11150 (2182171) 2182171..2182902 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
IF754_RS11155 (2182899) 2182899..2183618 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T174962 WP_000251928.1 NZ_CP062405:c2179067-2178801 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174962 NZ_CP081714:29953-30264 [Escherichia coli]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT174962 WP_000584497.1 NZ_CP062405:c2179318-2179067 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT174962 NZ_CP081714:30261-30680 [Escherichia coli]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTTCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References