Detailed information of TA system TA174946

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2163114..2163298
• Replicon: chromosome
• Accession: NZ_CP062404
• Organism: Staphylococcus aureus strain NAS_NP_229

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF757_RS10920
• Protein ID: WP_000482647.1
• Coordinates: 2163191..2163298 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2163114..2163174 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF757_RS10905	2158624..2158791	-	168	Protein_2105	hypothetical protein	-
IF757_RS10910	2159022..2160755	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
IF757_RS10915	2160780..2162543	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	2163114..2163174	+	61	-	-	Antitoxin
IF757_RS10920	2163191..2163298	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF757_RS10925	2163432..2163818	-	387	WP_000779351.1	flippase GtxA	-
IF757_RS10930	2164086..2165228	+	1143	WP_001176855.1	glycerate kinase	-
IF757_RS10935	2165288..2165947	+	660	WP_000831298.1	membrane protein	-
IF757_RS10940	2166129..2167340	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
IF757_RS10945	2167463..2167936	-	474	WP_224212098.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174946 WP_000482647.1 NZ_CP062404:c2163298-2163191 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174946 NZ_CP081713:1068120-1068455 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAAGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT174946 NZ_CP062404:2163114-2163174 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin