Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2137882..2138399 | Replicon | chromosome |
Accession | NZ_CP062404 | ||
Organism | Staphylococcus aureus strain NAS_NP_229 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A170NWK0 |
Locus tag | IF757_RS10785 | Protein ID | WP_000251928.1 |
Coordinates | 2137882..2138148 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A166LMC5 |
Locus tag | IF757_RS10790 | Protein ID | WP_000584497.1 |
Coordinates | 2138148..2138399 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IF757_RS10760 (2133090) | 2133090..2133626 | - | 537 | WP_000024292.1 | GNAT family N-acetyltransferase | - |
IF757_RS10765 (2134094) | 2134094..2134918 | - | 825 | WP_000594640.1 | formate/nitrite transporter family protein | - |
IF757_RS10770 (2135121) | 2135121..2135303 | - | 183 | WP_000079140.1 | hypothetical protein | - |
IF757_RS10775 (2135389) | 2135389..2135856 | - | 468 | WP_000153340.1 | SRPBCC domain-containing protein | - |
IF757_RS10780 (2136042) | 2136042..2137589 | - | 1548 | WP_000727771.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
IF757_RS10785 (2137882) | 2137882..2138148 | - | 267 | WP_000251928.1 | Txe/YoeB family addiction module toxin | Toxin |
IF757_RS10790 (2138148) | 2138148..2138399 | - | 252 | WP_000584497.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
IF757_RS10795 (2138563) | 2138563..2138663 | - | 101 | Protein_2083 | hypothetical protein | - |
IF757_RS10800 (2138670) | 2138670..2139269 | - | 600 | WP_000162804.1 | DsbA family protein | - |
IF757_RS10805 (2139288) | 2139288..2139650 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
IF757_RS10810 (2139905) | 2139905..2141155 | + | 1251 | WP_001012237.1 | FemA/FemB family glycyltransferase FmhA | - |
IF757_RS10815 (2141252) | 2141252..2141983 | - | 732 | WP_000615467.1 | amino acid ABC transporter ATP-binding protein | - |
IF757_RS10820 (2141980) | 2141980..2142699 | - | 720 | WP_000479573.1 | amino acid ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10465.06 Da Isoelectric Point: 10.1628
>T174945 WP_000251928.1 NZ_CP062404:c2138148-2137882 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174945 NZ_CP081713:928603-929010 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9401.54 Da Isoelectric Point: 4.3407
>AT174945 WP_000584497.1 NZ_CP062404:c2138399-2138148 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
Download Length: 252 bp
>AT174945 NZ_CP081713:928356-928622 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A170NWK0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A166LMC5 |