Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2329173..2329690 Replicon chromosome
Accession NZ_CP062403
Organism Staphylococcus aureus strain NAS_OP_052

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF765_RS11365 Protein ID WP_000113262.1
Coordinates 2329424..2329690 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF765_RS11360 Protein ID WP_000584499.1
Coordinates 2329173..2329424 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF765_RS11330 (2324871) 2324871..2325590 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF765_RS11335 (2325587) 2325587..2326318 + 732 WP_000615470.1 amino acid ABC transporter ATP-binding protein -
IF765_RS11340 (2326415) 2326415..2327665 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF765_RS11345 (2327920) 2327920..2328282 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF765_RS11350 (2328301) 2328301..2328900 + 600 WP_000162813.1 DsbA family protein -
IF765_RS11355 (2328907) 2328907..2329008 + 102 WP_001791744.1 hypothetical protein -
IF765_RS11360 (2329173) 2329173..2329424 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF765_RS11365 (2329424) 2329424..2329690 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF765_RS11370 (2329725) 2329725..2329796 + 72 Protein_2209 hypothetical protein -
IF765_RS11375 (2329985) 2329985..2331535 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF765_RS11380 (2331721) 2331721..2332188 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF765_RS11385 (2332272) 2332272..2332454 + 183 WP_000230294.1 hypothetical protein -
IF765_RS11390 (2332671) 2332671..2333495 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF765_RS11395 (2333728) 2333728..2334264 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174927 WP_000113262.1 NZ_CP062403:2329424-2329690 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174927 NZ_CP081711:1797543-1797797 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174927 WP_000584499.1 NZ_CP062403:2329173-2329424 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174927 NZ_CP081711:1797295-1797546 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References