Detailed information of TA system TA174927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2329173..2329690
• Replicon: chromosome
• Accession: NZ_CP062403
• Organism: Staphylococcus aureus strain NAS_OP_052

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YC79
• Locus tag: IF765_RS11365
• Protein ID: WP_000113262.1
• Coordinates: 2329424..2329690 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: IF765_RS11360
• Protein ID: WP_000584499.1
• Coordinates: 2329173..2329424 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF765_RS11330 (2324871)	2324871..2325590	+	720	WP_000479576.1	amino acid ABC transporter permease	-
IF765_RS11335 (2325587)	2325587..2326318	+	732	WP_000615470.1	amino acid ABC transporter ATP-binding protein	-
IF765_RS11340 (2326415)	2326415..2327665	-	1251	WP_001012222.1	FemA/FemB family glycyltransferase FmhA	-
IF765_RS11345 (2327920)	2327920..2328282	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
IF765_RS11350 (2328301)	2328301..2328900	+	600	WP_000162813.1	DsbA family protein	-
IF765_RS11355 (2328907)	2328907..2329008	+	102	WP_001791744.1	hypothetical protein	-
IF765_RS11360 (2329173)	2329173..2329424	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF765_RS11365 (2329424)	2329424..2329690	+	267	WP_000113262.1	Txe/YoeB family addiction module toxin	Toxin
IF765_RS11370 (2329725)	2329725..2329796	+	72	Protein_2209	hypothetical protein	-
IF765_RS11375 (2329985)	2329985..2331535	+	1551	WP_000727763.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
IF765_RS11380 (2331721)	2331721..2332188	+	468	WP_000153344.1	SRPBCC domain-containing protein	-
IF765_RS11385 (2332272)	2332272..2332454	+	183	WP_000230294.1	hypothetical protein	-
IF765_RS11390 (2332671)	2332671..2333495	+	825	WP_000572040.1	formate/nitrite transporter family protein	-
IF765_RS11395 (2333728)	2333728..2334264	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.95 Da
• Isoelectric Point: 9.9143

>T174927 WP_000113262.1 NZ_CP062403:2329424-2329690 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T174927 NZ_CP081711:1797543-1797797 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT174927 WP_000584499.1 NZ_CP062403:2329173-2329424 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT174927 NZ_CP081711:1797295-1797546 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7CUA
• PDB: 6L8E

Antitoxin

• AlphaFold DB: T1YB60