Detailed information of TA system TA174925

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2304258..2304442
• Replicon: chromosome
• Accession: NZ_CP062403
• Organism: Staphylococcus aureus strain NAS_OP_052

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: IF765_RS11230
• Protein ID: WP_072467491.1
• Coordinates: 2304258..2304365 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2304382..2304442 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF765_RS11205	2299631..2300104	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF765_RS11210	2300227..2301438	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF765_RS11215	2301620..2302279	-	660	WP_000831298.1	membrane protein	-
IF765_RS11220	2302339..2303481	-	1143	WP_064129935.1	glycerate kinase	-
IF765_RS11225	2303738..2304124	+	387	WP_000779348.1	flippase GtxA	-
IF765_RS11230	2304258..2304365	+	108	WP_072467491.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2304382..2304442	-	61	-	-	Antitoxin
IF765_RS11235	2304955..2306718	+	1764	WP_001064834.1	ABC transporter ATP-binding protein	-
IF765_RS11240	2306743..2308476	+	1734	WP_000486502.1	ABC transporter ATP-binding protein	-
IF765_RS11245	2308707..2308874	+	168	WP_031866196.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3944.67 Da
• Isoelectric Point: 10.4934

>T174925 WP_072467491.1 NZ_CP062403:2304258-2304365 [Staphylococcus aureus]
IFNLLIDIMTSAISGCLVAFFANWLRTRSNKKGDK

Nucleotide

• Length: 108 bp

>T174925 NZ_CP081711:1016392-1016727 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT174925 NZ_CP062403:c2304442-2304382 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Antitoxin