Detailed information of TA system TA174924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2272900..2273423
• Replicon: chromosome
• Accession: NZ_CP062403
• Organism: Staphylococcus aureus strain NAS_OP_052

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IF765_RS11100
• Protein ID: WP_000074046.1
• Coordinates: 2273157..2273423 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: IF765_RS11095
• Protein ID: WP_000587615.1
• Coordinates: 2272900..2273157 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF765_RS11075 (2267995)	2267995..2269188	+	1194	WP_000675403.1	MFS transporter	-
IF765_RS11080 (2269412)	2269412..2270161	-	750	WP_000019956.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF765_RS11085 (2270351)	2270351..2271928	+	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
IF765_RS11090 (2272078)	2272078..2272542	-	465	WP_000736689.1	DUF1307 domain-containing protein	-
IF765_RS11095 (2272900)	2272900..2273157	+	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF765_RS11100 (2273157)	2273157..2273423	+	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
IF765_RS11105 (2273736)	2273736..2274812	+	1077	WP_001076667.1	M42 family metallopeptidase	-
IF765_RS11110 (2275060)	2275060..2275722	+	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
IF765_RS11115 (2275715)	2275715..2276488	+	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
IF765_RS11120 (2276840)	2276840..2278024	+	1185	WP_000115415.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T174924 WP_000074046.1 NZ_CP062403:2273157-2273423 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174924 NZ_CP081711:877225-877632 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT174924 WP_000587615.1 NZ_CP062403:2272900-2273157 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174924 NZ_CP081711:876978-877244 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2