Detailed information of TA system TA174921

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 169285..169465
• Replicon: chromosome
• Accession: NZ_CP062403
• Organism: Staphylococcus aureus strain NAS_OP_052

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF765_RS01060
• Protein ID: WP_001801861.1
• Coordinates: 169370..169465 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	169285..169342 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF765_RS01030	165636..166754	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
IF765_RS01035	167402..167845	+	444	WP_000742594.1	DUF1433 domain-containing protein	-
IF765_RS01040	168124..168402	+	279	WP_001798632.1	DUF1433 domain-containing protein	-
IF765_RS01045	168424..168798	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF765_RS01050	168986..169168	+	183	Protein_171	transposase	-
IF765_RS01055	169146..169247	-	102	WP_001791232.1	hypothetical protein	-
-	169285..169342	+	58	-	-	Antitoxin
IF765_RS01060	169370..169465	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF765_RS01065	169916..170362	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF765_RS01070	171047..171430	+	384	WP_000070811.1	hypothetical protein	-
IF765_RS01075	171441..171617	+	177	WP_000375476.1	hypothetical protein	-
IF765_RS01080	171917..172545	+	629	Protein_177	ImmA/IrrE family metallo-endopeptidase	-
IF765_RS01085	172743..173315	-	573	Protein_178	hypothetical protein	-
IF765_RS01090	173416..173757	-	342	WP_000627548.1	DUF3969 family protein	-
IF765_RS01095	173798..174424	-	627	WP_000669019.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	147749..176984	29235

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174921 WP_001801861.1 NZ_CP062403:c169465-169370 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174921 NZ_CP081711:c633298-632834 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174921 NZ_CP062403:169285-169342 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin