Detailed information of TA system TA174915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2420921..2421444
• Replicon: chromosome
• Accession: NZ_CP062402
• Organism: Staphylococcus aureus strain NAS_OP_056

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: IF766_RS11925
• Protein ID: WP_000074043.1
• Coordinates: 2420921..2421187 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: IF766_RS11930
• Protein ID: WP_000587618.1
• Coordinates: 2421187..2421444 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF766_RS11905 (IF766_11840)	2416226..2417413	-	1188	WP_000026187.1	MFS transporter	-
IF766_RS11910 (IF766_11845)	2417809..2418585	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
IF766_RS11915 (IF766_11850)	2418578..2419240	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
IF766_RS11920 (IF766_11855)	2419489..2420565	-	1077	WP_001076665.1	M42 family metallopeptidase	-
IF766_RS11925 (IF766_11860)	2420921..2421187	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
IF766_RS11930 (IF766_11865)	2421187..2421444	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF766_RS11935 (IF766_11870)	2421804..2422259	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
IF766_RS11940 (IF766_11875)	2422427..2424004	-	1578	WP_000143508.1	FMN-binding glutamate synthase family protein	-
IF766_RS11945 (IF766_11880)	2424199..2424948	+	750	WP_000072441.1	CPBP family lipoprotein N-acylation protein LnsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T174915 WP_000074043.1 NZ_CP062402:c2421187-2420921 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174915 NZ_CP081706:3764003-3764344 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT174915 WP_000587618.1 NZ_CP062402:c2421444-2421187 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174915 NZ_CP081706:3763665-3763982 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2