Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2389739..2389923 Replicon chromosome
Accession NZ_CP062402
Organism Staphylococcus aureus strain NAS_OP_056

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag IF766_RS11785 Protein ID WP_000482650.1
Coordinates 2389816..2389923 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2389739..2389799 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF766_RS11770 (IF766_11705) 2385249..2385416 - 168 WP_001792506.1 hypothetical protein -
IF766_RS11775 (IF766_11710) 2385647..2387380 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
IF766_RS11780 (IF766_11715) 2387405..2389168 - 1764 WP_001064820.1 ABC transporter ATP-binding protein -
- 2389739..2389799 + 61 - - Antitoxin
IF766_RS11785 (IF766_11720) 2389816..2389923 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
IF766_RS11790 (IF766_11725) 2390057..2390443 - 387 WP_000779358.1 flippase GtxA -
IF766_RS11795 (IF766_11730) 2390701..2391843 + 1143 WP_001176863.1 glycerate kinase -
IF766_RS11800 (IF766_11735) 2391903..2392562 + 660 WP_000831298.1 membrane protein -
IF766_RS11805 (IF766_11740) 2392744..2393955 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
IF766_RS11810 (IF766_11745) 2394078..2394551 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T174913 WP_000482650.1 NZ_CP062402:c2389923-2389816 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T174913 NZ_CP081706:2803456-2803563 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 61 bp

>AT174913 NZ_CP062402:2389739-2389799 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References